Why spermadina is great for your longevity

If you’ve never heard of spermadine, now is the right time to learn about the youth-boosting compound. But don’t let her strange name fool you. Spermadine is actually one of the most studied compounds in the science of longevity. And the good news is, you can easily include it in your diet or supplement it. Here’s what you need to know.

What is spermidine?

Spermadine was first discovered and named by Dutch microscopist Anton Van Leeuwenhoek in 1687. It is a polyminic compound and is not found exclusively in semen, a fact that can be distracting, when in fact spermadine is found in many normal food sources .

Why is this such a hot topic in the science of longevity?

spermadine plays a vital role in cellular function and survival. Studies have shown that polyamine levels decline with age.

One she studies actually found that higher survival rates among humans were linked to increased spermidine intake.

The link between longevity and spermadine

Spermadine is getting airtime because it holds a lot of promise when it comes to longevity. To ask David Sinclair, PhD, recognized aging expert. He posted this comment recently.

Protects against heart disease

Spermidine can also reduce blood pressure levels. It will reduce the risk of cardiac hypertrophy, heart failure and other cardiovascular diseases.

It stimulates autophagy

Simply explained, autophagy is the cell’s recycling mechanism. Think of it as the body’s spring cleansing process, in which it cleanses dysfunctional and damaged cells and regenerates itself through creating newer, healthier cells.

Strengthens the immune system

Spermidine is also an important factor in regulating the immune system at various levels.

According to Nature, “Treatment with spermidine has been shown to extend the lifespan of yeasts, flies, worms, mammalian cells and mice and leads to cardio protection and improved cognitive function in aging mice.”

Fights neurodegenerative diseases

Taking spermidine supplements can reverse the neurological damage caused by inflammation and oxidative stress. spermadine plays a vital role in cellular function and survival

As a result, it can help reduce the risk of suffering from neurodegenerative diseases such as Alzheimer’s and Parkinson’s disease.

Alters lipid metabolism

Lipid metabolism is the synthesis and breakdown of lipids in cells. This involves the breakdown or storage of fats for energy, as well as the synthesis of structural and functional lipids, such as those involved in the construction of cell membranes. Lipid metabolism is a strong regulator of health and life span.

Therefore, a dysfunction can have a negative impact on health and life span. this is where spermadine comes in and positively helps the dysregulation process!

Reduces inflammation

Aging is strongly linked to chronic inflammation which in turn leads to chronic cell damage. Inflammation is associated with many age-related diseases. The good news is that research shows that polyamines like spermadine have an anti-inflammatory effect.

Decreases the risk of cancer

Studies have found that eating a spermidine-rich diet could potentially reduce the risk of death from cancer in humans. For example, spermidine can prevent liver fibrosis and hepatocellular carcinoma. These are some of the more common causes of liver cancer.

What foods contain spermidine?

The super compound is found in fresh green pepper, wheat germ, cauliflower, broccoli, mushrooms and a variety of cheeses. Even greater quantities are found in soy products. These include natto, shitake mushrooms, amaranth grain, and durian. This may explain why the Japanese have such good longevity. Take for example the the okinawa.They live on a small island off the coast of Japan and eat a diet rich in spermadins.

Some fruits and vegetables contain spermadine and can be found in the Mediterranean diet. known for promoting longevity.

spermadine [longevity live]

Here are the 16 best foods to include in your diet

  1. Wheat germ
  2. Amaranth grain
  3. Whole wheat
  4. Chickpeas
  5. Cauliflower
  6. Broccoli
  7. Fresh green pepper
  8. Mushrooms (especially shitake mushrooms)
  9. Nat-to
  10. Durian
  11. Grape
  12. Oranges
  13. Green tea
  14. Legumes
  15. Some aged cheeses
  16. Soy products

What about integration?

Can we get enough spermadine in our diet? Well, there is always a debate on that. However, there is a fair amount of literature supporting the case for using supplements. This is in addition to having a good, healthy diet of course.

These supplements are made up of synthetic spermidine which is identical to the natural molecule. However, don’t shop blindly. Make sure you buy from a reputable source.

How to choose the right spermadine supplement?

Integration rules vary by country. You will need to do some basic regulatory research if you live outside the US or buy a non-US product.

As a basic rule, all supplements would be labeled with information relating to their manufacturing practices. They will also identify the country in which they are produced and by which they are regulated.

Buy wisely

To ensure that a dietary supplement is of high quality and not contaminated with other materials, purchase products with labels that prove they have been tested by an independent, non-profit body. as the United States Pharmacopoeia Convention (USP) Food Supplement Verification Program. or ConsumerLab.com.

Buy food supplements made in countries with consumer protection regulations and from established retail outlets.

Research a product before buying it and check reviews, especially the value of the usage report, as well as any negative reactions. You can also watch the About herbswebsite, which also helps you understand the ingredients and what to pay attention to.

The bottom line

The name might raise eyebrows. However, if research is anything to go by, this super compound will help you live better longer naturally.


Lifespan: spermadina: https://www.lifespan.io/news/a-summary-of-spermidine
Nature: https://www.nature.com/articles/s41598-022-08168-2
Minois N, Carmona-Gutierrez D, Madeo F: Polyamines in aging and disease. Aging 2011; 3: 716-732
Pucciarelli S, Moreschini B, Micozzi D, De Fronzo GS, Carpi FM, Polzonetti V, Vincenzetti S, Mignini F, Napolioni V: Spermidine and spermine are enriched in whole-blood of nona / centenarians. Rejuv Res 2012; 15: 590-595
Soda K, Kano Y, Sakuragi M, Takao K, Lefor A, Konishi F: Long-term oral polyamine intake increases blood polyamine concentrations. J Nutr Sci Vitaminol 2009; 55: 361-366
Soda K, Dobashi Y, Kano Y, Tsujinaka S, Konishi F: Polyamine-rich food reduces age-associated pathology and mortality in aged mice. Ex Gerontol 2009; 44: 727-732
Morselli E, Marino G, Bennetzen MV, Eisenberg T, Megalou E, Schroeder S, Cabrera S, Benite P, Rustin P, Criollo A, Kepp O, Galluzzi L, Shen S, Malik SA, Maiuri MC, Horio Y, Lopez- Otin C, Andersen JS, Tavernarakis N, Madeo F, Kroemer G: Spermidin and resveratrol induce autophagy by distinct pathways converging on acetylproteome. J Cell Biol 2011; 192: 615–629.
Minois N, Carmona-Gutierrez D, Bauer MA, Rockenfeller P, Eisenberg T, Brandhorst S, Sisgrist SJ, Kroemer G, Madeo F: Spermidine promotes stress resistance in Drosophila melanogaster through autophagic and independent pathways. Cell death Dis 2012; 3: e401.
Choi YH, Park HY: Anti-inflammatory effects of spermidine in BV2 microglial cells stimulated with lipopolysaccharides. J Biomed Sci 2012; 19: 31.
Paul S, Kang SC: Natural polyamine inhibits mouse skin inflammation and macrophage activation. Inflamm Ris 2013; 62: 681-688.
Capra S, Pirinen E, Cerrada-Gimenez M, Keinänen TA, Uimari M, Khomutov AR, Jänne J, Alhonen L: Spermidine is indispensable in the differentiation of 3T3-L1 fibroblasts in adipocytes. J Cell Mol Med 2010; 14: 1683-1692.
Ishii I, Ikeguchi Y, Mano H, Wada M, Pegg AE, Shirahata A: Polyamine metabolism is involved in the adipogenesis of 3T3-L1 cells. Amino Acids 2012; 42: 619-626
Maccarrone M, Bari M, Battista N, Di Rienzo M, Falciglia K, Finazzi Agrò A: The oxidation products of polyamines induce mitochondrial decoupling and release of cytochrome c. FEBS Lett 2001; 507: 30-34.
Bennetzen MV, Marino G, Pultz D, Morselli E, Faergeman NJ, Kroemer G, Andersen JS: Phosphoproteomic analysis of cells treated with autophagy inducers linked to longevity. Cell Cycle 2012; 11: 1827-1840.
Vellai T, Takács-Vellai K, Sass M, Klionsky DJ: The regulation of aging: is autophagy the basis of longevity? Cell Biol Trends 2009; 19: 487-494
Stark F, Pfannstiel J, Klaiber I, Raabe T: Protein kinase CK2 links polyamine metabolism to MAPK signaling in Drosophila. Cell Signal 2011; 23: 876-882